Professor Robin Lee's research at the University of Pittsburgh focuses on the design and dynamics of molecular circuits involved in inflammatory signal transduction. His lab employs live-cell imaging, microfluidics, and computational modeling to analyze how single cells process environmental signals through complex signaling pathways. By investigating how variations in protein abundance impact cell fate decisions, his work aims to develop mathematical models that elucidate the mechanisms underlying inflammation and cancer. This understanding could lead to targeted interventions in diseases characterized by dysregulated signaling.
"NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity"
Kim AH, Krummenacher B, Yeung J, Koes DR, Lee REC. Cell Rep. 2025, 44, 12, 116637
"Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics"
Smeal SW, Mokashi CS, Kim AH, Chiknas PM, Lee REC. Nat Commun. 2025, 16, 1, 7329
"Ubiquitin: Not just a one-way ticket to the proteasome, but a therapeutic dial to fine-tune the molecular landscape of disease"
Kim AH, Chiknas PM, Lee REC. Clin Transl Med. 2024, 14, 7, e1769
"A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB"
Cruz JA, Mokashi CS, Kowalczyk GJ, Guo Y, Zhang Q, Gupta S, Schipper DL, Smeal SW, Lee REC. Sci Adv. 2021, 7, 30, eabi9410
"Long-term imaging of individual mRNA molecules in living cells"
Guo Y, Lee REC. Cell Rep Methods. 2022, 2, 6, 100226