Professor Keisuke Ishihara's research focuses on synthetic morphogenesis, particularly in understanding and engineering the form and function of multicellular tissues. His lab uses a combination of genetic, chemical, and computational tools to study how cells generate complex 3D structures, such as organoids. The group has pioneered neuroepithelial and cardiac organoid models to investigate how tissue architecture influences function, aiming to reveal fundamental principles of tissue morphogenesis. Ishihara's work has applications in organ engineering, with a focus on predictive modeling and quantitative control of tissue structures.
"Synthetic lumen rounding directs neural progenitor division mode"
Marchenko M, Martinez Ara G, Pulikkal J, Ishihara K, Ebisuya M bioRxiv (preprint) 2026
"Hyaluronan underlies the emergence of form, fate, and function in human cardioids"
Jahnel SM, Dimitriadi A, Kodnar J, Gerakopoulos V, Khurana Y, Mayrhauser M, Ilmer T, Ishihara K, Mendjan S bioRxiv (preprint) 2026
"The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after mitosis"
Bragulat-Teixidor H, Ishihara K, Szücs GM, Otsuka S. EMBO Rep. 2024, 25, 7, 3137-3159
"Topological morphogenesis of neuroepithelial organoids"
Ishihara K, Mukherjee A, Gromberg E, Brugués J, Tanaka EM, Jülicher F. Nat Phys. 2023, 19, 2, 177-183
"Spatial variation of microtubule depolymerization in large asters"
Ishihara K, Decker F, Caldas P, Pelletier JF, Loose M, Brugués J, Mitchison TJ. Mol Biol Cell. 2021, 32, 9, 869-879